| Ident. | Authors (with country if any) | Title |
|---|
| 000110 (2020) |
Guangdi Li ; Erik De Clercq | Therapeutic options for the 2019 novel coronavirus (2019-nCoV). |
| 000C54 (2018) |
Brian L. Venables [États-Unis] ; Ny Sin [États-Unis] ; Alan Xiangdong Wang [États-Unis] ; Li-Qiang Sun [États-Unis] ; Yong Tu [États-Unis] ; Dennis Hernandez [États-Unis] ; Amy Sheaffer [États-Unis] ; Min Lee [États-Unis] ; Cindy Dunaj [États-Unis] ; Guangzhi Zhai [États-Unis] ; Diana Barry [États-Unis] ; Jacques Friborg [États-Unis] ; Fei Yu [États-Unis] ; Jay Knipe [États-Unis] ; Jason Sandquist [États-Unis] ; Paul Falk [États-Unis] ; Dawn Parker [États-Unis] ; Andrew C. Good [États-Unis] ; Ramkumar Rajamani [États-Unis] ; Fiona Mcphee [États-Unis] ; Nicholas A. Meanwell [États-Unis] ; Paul M. Scola [États-Unis] | P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor. |
| 000E21 (2017) |
Vathan Kumar [Taïwan] ; Jin Soo Shin [Corée du Sud] ; Jiun-Jie Shie [Taïwan] ; Keun Bon Ku [Corée du Sud] ; Chonsaeng Kim [Corée du Sud] ; Yun Young Go [Corée du Sud] ; Kai-Fa Huang [Taïwan] ; Meehyein Kim [Corée du Sud] ; Po-Huang Liang [Taïwan] | Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CLPro inhibitors. |
| 000E38 (2017) |
Ji-Young Park [Corée du Sud] ; Heung Joo Yuk [Corée du Sud] ; Hyung Won Ryu [Corée du Sud] ; Su Hwan Lim [Corée du Sud] ; Kyung Su Kim [Corée du Sud] ; Ki Hun Park [Corée du Sud] ; Young Bae Ryu [Corée du Sud] ; Woo Song Lee [Corée du Sud] | Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors. |
| 000E50 (2017) |
Li Wang [République populaire de Chine] ; Bo-Bo Bao [République populaire de Chine] ; Guo-Qing Song [République populaire de Chine] ; Cheng Chen [République populaire de Chine] ; Xu-Meng Zhang [République populaire de Chine] ; Wei Lu [République populaire de Chine] ; Zefang Wang [République populaire de Chine] ; Yan Cai [République populaire de Chine] ; Shuang Li [République populaire de Chine] ; Sheng Fu [République populaire de Chine] ; Fu-Hang Song [République populaire de Chine] ; Haitao Yang [République populaire de Chine] ; Jian-Guo Wang [République populaire de Chine] | Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease: Chemical synthesis, biological evaluation, molecular docking and 3D-QSAR study |
| 000E63 (2017) |
Kazuya Shirato [Japon] ; Kazuhiko Kanou [Japon] ; Miyuki Kawase [Japon] ; Shutoku Matsuyama [Japon] | Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry. |
| 000F38 (2016) |
Fenghua Wang [République populaire de Chine] ; Cheng Chen [République populaire de Chine] ; Wenjie Tan [République populaire de Chine] ; Kailin Yang [États-Unis] ; Haitao Yang [République populaire de Chine] | Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design |
| 000F54 (2016) |
Haofeng Wang ; Song Xue ; Haitao Yang ; Cheng Chen | Recent progress in the discovery of inhibitors targeting coronavirus proteases |
| 001007 (2016) |
Vathan Kumar [Taïwan] ; Kian-Pin Tan [Taïwan] ; Ying-Ming Wang [Taïwan] ; Sheng-Wei Lin [Taïwan] ; Po-Huang Liang [Taïwan] | Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors. |
| 001053 (2016) |
Hiroyuki Konno [Japon] ; Masaki Wakabayashi [Japon] ; Daiki Takanuma [Japon] ; Yota Saito [Japon] ; Kenichi Akaji [Japon] | Design and synthesis of a series of serine derivatives as small molecule inhibitors of the SARS coronavirus 3CL protease |
| 001056 (2016) |
Fenghua Wang [République populaire de Chine] ; Cheng Chen [République populaire de Chine] ; Xuemeng Liu [République populaire de Chine] ; Kailin Yang [États-Unis] ; Xiaoling Xu [République populaire de Chine] ; Haitao Yang [République populaire de Chine] | Crystal Structure of Feline Infectious Peritonitis Virus Main Protease in Complex with Synergetic Dual Inhibitors. |
| 001105 (2016) |
Kenta Teruya [Japon] ; Yasunao Hattori [Japon] ; Yasuhiro Shimamoto [Japon] ; Kazuya Kobayashi [Japon] ; Akira Sanjoh [Japon] ; Atsushi Nakagawa [Japon] ; Eiki Yamashita [Japon] ; Kenichi Akaji [Japon] | Structural basis for the development of SARS 3CL protease inhibitors from a peptide mimic to an aza‐decaline scaffold |
| 001227 (2015) |
Sarah E. St. John [États-Unis] ; Sakshi Tomar [États-Unis] ; Shaun R. Stauffer [États-Unis] ; Andrew D. Mesecar [États-Unis] | Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4—The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS) |
| 001266 (2015) |
Yanchen Zhou [États-Unis] ; Punitha Vedantham [États-Unis] ; Kai Lu [États-Unis] ; Juliet Agudelo [États-Unis] ; Ricardo Carrion [États-Unis] ; Jerritt W. Nunneley [États-Unis] ; Dale Barnard [États-Unis] ; Stefan Pöhlmann [Allemagne] ; James H. Mckerrow [États-Unis] ; Adam R. Renslo [États-Unis] ; Graham Simmons [États-Unis] | Protease inhibitors targeting coronavirus and filovirus entry. |
| 001297 (2015) |
Hyun Lee [États-Unis] ; Hao Lei [États-Unis] ; Bernard D. Santarsiero [États-Unis] ; Joseph L. Gatuz [États-Unis] ; Shuyi Cao [États-Unis] ; Amy J. Rice [États-Unis] ; Kavankumar Patel [États-Unis] ; Michael Z. Szypulinski [États-Unis] ; Isabel Ojeda ; Arun K. Ghosh [États-Unis] ; Michael E. Johnson [États-Unis] | Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV. |
| 001541 (2014) |
Paul M. Scola [États-Unis] ; Li-Qiang Sun ; Alan Xiangdong Wang ; Jie Chen ; Ny Sin ; Brian L. Venables ; Sing-Yuen Sit ; Yan Chen ; Anthony Cocuzza ; Donna M. Bilder ; Stanley V. D'Andrea ; Barbara Zheng ; Piyasena Hewawasam ; Yong Tu ; Jacques Friborg ; Paul Falk ; Dennis Hernandez ; Steven Levine ; Chaoqun Chen ; Fei Yu ; Amy K. Sheaffer ; Guangzhi Zhai ; Diana Barry ; Jay O. Knipe ; Yong-Hae Han ; Richard Schartman ; Maria Donoso ; Kathy Mosure ; Michael W. Sinz ; Tatyana Zvyaga ; Andrew C. Good ; Ramkumar Rajamani ; Kevin Kish ; Jeffrey Tredup ; Herbert E. Klei ; Qi Gao ; Luciano Mueller ; Richard J. Colonno ; Dennis M. Grasela ; Stephen P. Adams ; James Loy ; Paul C. Levesque ; Huabin Sun ; Hong Shi ; Lucy Sun ; William Warner ; Danshi Li ; Jialong Zhu ; Nicholas A. Meanwell ; Fiona Mcphee | The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection. |
| 001563 (2014) |
K B Wong [Hong Kong] ; D C C. Wan [Hong Kong] ; H F Chow [Hong Kong] | Substrate specificity and rational design of peptidomimetic inhibitors for SARS coronavirus main protease. |
| 001594 (2014) |
C P Chuck [Hong Kong] ; Z H Ke [Hong Kong] ; C. Chen [Hong Kong] ; D C C. Wan [Hong Kong] ; H F Chow [Hong Kong] ; K B Wong [Hong Kong] | Profiling of substrate-specificity and rational design of broad-spectrum peptidomimetic inhibitors for main proteases of coronaviruses. |
| 001647 (2014) |
Yasuhiro Shimamoto [Japon] ; Yasunao Hattori [Japon] ; Kazuya Kobayashi [Japon] ; Kenta Teruya [Japon] ; Akira Sanjoh [Japon] ; Atsushi Nakagawa [Japon] ; Eiki Yamashita [Japon] ; Kenichi Akaji [Japon] | Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors |
| 001650 (2014) |
Rolf Hilgenfeld | From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design |
| 001676 (2014) |
Xufang Deng [États-Unis] ; Sarah E. Stjohn [États-Unis] ; Heather L. Osswald [États-Unis] ; Amornrat O'Brien [États-Unis] ; Bridget S. Banach [États-Unis] ; Katrina Sleeman [États-Unis] ; Arun K. Ghosh [États-Unis] ; Andrew D. Mesecar [États-Unis] ; Susan C. Baker [États-Unis] | Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance. |
| 001834 (2013) |
Zhilin Ren [République populaire de Chine] ; Liming Yan ; Ning Zhang ; Yu Guo ; Cheng Yang ; Zhiyong Lou ; Zihe Rao | The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease. |
| 001847 (2013) |
Wei Liu [République populaire de Chine] ; He-Min Zhu [République populaire de Chine] ; Guo-Jun Niu [République populaire de Chine] ; En-Zhi Shi [République populaire de Chine] ; Jie Chen [République populaire de Chine] ; Bo Sun [République populaire de Chine] ; Wei-Qiang Chen [République populaire de Chine] ; Hong-Gang Zhou [République populaire de Chine] ; Cheng Yang [République populaire de Chine] | Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors |
| 001850 (2013) |
Hyun Lee [États-Unis] ; Shuyi Cao ; Kirk E. Hevener ; Lena Truong ; Joseph L. Gatuz ; Kavankumar Patel ; Arun K. Ghosh ; Michael E. Johnson | Synergistic inhibitor binding to the papain-like protease of human SARS coronavirus: mechanistic and inhibitor design implications. |
| 001876 (2013) |
Qi Zhao [États-Unis] ; Erin Weber ; Haitao Yang | Recent developments on coronavirus main protease/3C like protease inhibitors. |
| 001904 (2013) |
Sivakoteswara Rao Mandadapu [États-Unis] ; Pathum M. Weerawarna ; Allan M. Prior ; Roxanne Adeline Z. Uy ; Sridhar Aravapalli ; Kevin R. Alliston ; Gerald H. Lushington ; Yunjeong Kim ; Duy H. Hua ; Kyeong-Ok Chang ; William C. Groutas | Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus. |
| 001953 (2013) |
Jon Jacobs [États-Unis] ; Valerie Grum-Tokars ; Ya Zhou ; Mark Turlington ; S Adrian Saldanha ; Peter Chase ; Aimee Eggler ; Eric S. Dawson ; Yahira M. Baez-Santos ; Sakshi Tomar ; Anna M. Mielech ; Susan C. Baker ; Craig W. Lindsley ; Peter Hodder ; Andrew Mesecar ; Shaun R. Stauffer | Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease. |
| 001961 (2013) |
Pillaiyar Thanigaimalai [Japon] ; Sho Konno ; Takehito Yamamoto ; Yuji Koiwai ; Akihiro Taguchi ; Kentaro Takayama ; Fumika Yakushiji ; Kenichi Akaji ; Shen-En Chen ; Aurash Naser-Tavakolian ; Arne Schön ; Ernesto Freire ; Yoshio Hayashi | Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: design, synthesis, biological evaluation, and docking studies. |
| 001967 (2013) |
Sho Konno [Japon] ; Pillaiyar Thanigaimalai ; Takehito Yamamoto ; Kiyohiko Nakada ; Rie Kakiuchi ; Kentaro Takayama ; Yuri Yamazaki ; Fumika Yakushiji ; Kenichi Akaji ; Yoshiaki Kiso ; Yuko Kawasaki ; Shen-En Chen ; Ernesto Freire ; Yoshio Hayashi | Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety. |
| 001986 (2013) |
Andy Kilianski [États-Unis] ; Anna M. Mielech ; Xufang Deng ; Susan C. Baker | Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors. |
| 001991 (2013) |
Vathan Kumar ; Young-Sik Jung ; Po-Huang Liang | Anti-SARS coronavirus agents: a patent review (2008 - present). |
| 001C75 (2012) |
Hyun Lee [États-Unis] ; Jaime Torres ; Lena Truong ; Rima Chaudhuri ; Anuradha Mittal ; Michael E. Johnson | Reducing agents affect inhibitory activities of compounds: results from multiple drug targets. |
| 001D21 (2012) |
Thi Thanh Hanh Nguyen [Corée du Sud] ; Hye-Jin Woo ; Hee-Kyoung Kang ; Van Dao Nguyen ; Young-Min Kim ; Do-Won Kim ; Sul-Ah Ahn ; Yongmei Xia ; Doman Kim | Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris. |
| 002011 (2011) |
Thi Thanh Hanh Nguyen [Corée du Sud] ; Hwa-Ja Ryu ; Se-Hoon Lee ; Soonwook Hwang ; Vincent Breton ; Joon Haeng Rhee ; Doman Kim | Virtual screening identification of novel severe acute respiratory syndrome 3C-like protease inhibitors and in vitro confirmation. |
| 002028 (2011) |
Susanne Pfefferle [Allemagne] ; Julia Schöpf [Allemagne] ; Manfred Kögl [Allemagne] ; Caroline C. Friedel [Allemagne] ; Marcel A. Müller [Allemagne] ; Javier Carbajo-Lozoya [Allemagne] ; Thorsten Stellberger [Allemagne] ; Ekatarina Von Dall Rmi [Allemagne] ; Petra Herzog [Allemagne] ; Stefan Kallies [Allemagne] ; Daniela Niemeyer [Allemagne] ; Vanessa Ditt [Allemagne] ; Thomas Kuri [Allemagne] ; Roland Züst [Suisse] ; Ksenia Pumpor [Allemagne] ; Rolf Hilgenfeld [Allemagne] ; Frank Schwarz [Allemagne] ; Ralf Zimmer [Allemagne] ; Imke Steffen [Allemagne] ; Friedemann Weber [Allemagne] ; Volker Thiel [Suisse] ; Georg Herrler [Allemagne] ; Heinz-Jürgen Thiel [Allemagne] ; Christel Schwegmann-We Els [Allemagne] ; Stefan Pöhlmann [Allemagne] ; Jürgen Haas [Allemagne, Royaume-Uni] ; Christian Drosten [Allemagne] ; Albrecht Von Brunn [Allemagne] | The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors |
| 002059 (2011) |
R. Ramajayam [Taïwan] ; Kian-Pin Tan ; Po-Huang Liang | Recent development of 3C and 3CL protease inhibitors for anti-coronavirus and anti-picornavirus drug discovery. |
| 002075 (2011) |
Sheila M. Pimentel-Elardo ; Verena Buback ; Tobias A. M. Gulder ; Tim S. Bugni ; Jason Reppart ; Gerhard Bringmann ; Chris M. Ireland ; Tanja Schirmeister ; Ute Hentschel | New Tetromycin Derivatives with Anti-Trypanosomal and Protease Inhibitory Activities † |
| 002093 (2011) |
Prasenjit Mukherjee ; Falgun Shah ; Prashant Desai ; Mitchell Avery | Inhibitors of SARS-3CLpro: Virtual Screening, Biological Evaluation and Molecular Dynamics Simulation Studies |
| 002142 (2011) |
Rima Chaudhuri [États-Unis] ; Sishi Tang [États-Unis] ; Guijun Zhao [États-Unis] ; Hui Lu [États-Unis] ; David A. Case [États-Unis] ; Michael E. Johnson [États-Unis] | Comparison of SARS and NL63 Papain-Like Protease Binding Sites and Binding Site Dynamics: Inhibitor Design Implications |
| 002416 (2010) |
Matthijs Raaben [Pays-Bas] ; Clara C. Posthuma ; Monique H. Verheije ; Eddie G. Te Lintelo ; Marjolein Kikkert ; Jan W. Drijfhout ; Eric J. Snijder ; Peter J M. Rottier ; Cornelis A M. De Haan | The ubiquitin-proteasome system plays an important role during various stages of the coronavirus infection cycle. |
| 002434 (2010) |
R. Ramajayam [Taïwan] ; Kian-Pin Tan ; Hun-Ge Liu ; Po-Huang Liang | Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease. |
| 002437 (2010) |
R. Ramajayam [Taïwan] ; Kian-Pin Tan ; Hun-Ge Liu ; Po-Huang Liang | Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors. |
| 002469 (2010) |
Holger Steuber [Allemagne] ; Rolf Hilgenfeld | Recent advances in targeting viral proteases for the discovery of novel antivirals. |
| 002500 (2010) |
Chunmei Li [République populaire de Chine] ; Yifei Qi ; Xin Teng ; Zongchang Yang ; Ping Wei ; Changsheng Zhang ; Lei Tan ; Lu Zhou ; Ying Liu ; Luhua Lai | Maturation mechanism of severe acute respiratory syndrome (SARS) coronavirus 3C-like proteinase. |
| 002577 (2010) |
Young Bae Ryu [Corée du Sud] ; Hyung Jae Jeong ; Jang Hoon Kim ; Young Min Kim ; Ji-Young Park ; Doman Kim ; Thi Thanh Hanh Nguyen ; Su-Jin Park ; Jong Sun Chang ; Ki Hun Park ; Mun-Chual Rho ; Woo Song Lee | Biflavonoids from Torreya nucifera displaying SARS-CoV 3CL(pro) inhibition. |
| 002976 (2009) |
Jeffrey Anderson [États-Unis] ; Celia Schiffer ; Sook-Kyung Lee ; Ronald Swanstrom | Viral protease inhibitors. |
| 002989 (2009) |
Xin Chen [Taïwan] ; Chi-Yuan Chou ; Gu-Gang Chang | Thiopurine analogue inhibitors of severe acute respiratory syndrome-coronavirus papain-like protease, a deubiquitinating and deISGylating enzyme. |
| 002A32 (2009) |
D Y Jin [République populaire de Chine] ; B J Zheng | Roles of spike protein in the pathogenesis of SARS coronavirus. |
| 002A66 (2009) |
Thomas Regnier [Japon] ; Diganta Sarma ; Koushi Hidaka ; Usman Bacha ; Ernesto Freire ; Yoshio Hayashi ; Yoshiaki Kiso | New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors. |
| 002A96 (2009) |
Chih-Jung Kuo ; Hun-Ge Liu ; Yueh-Kuei Lo ; Churl-Min Seong ; Kee-In Lee ; Young-Sik Jung ; Po-Huang Liang | Individual and common inhibitors of coronavirus and picornavirus main proteases |
| 002B35 (2009) |
Tommy R. Tong [États-Unis] | Drug targets in severe acute respiratory syndrome (SARS) virus and other coronavirus infections. |
